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The reason may be related to the high activity of brain nerves

However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2

The treatment with cabergoline for 24 month normalizes the quality of seminal fluid in hyperprolactinemic males

Injectable forms remain the benchmark for consistent systemic exposure, though local or compartmental activity may be feasible for some molecules designed for oral stability